Defenders of science-based medicine are often confronted with the question (challenged, really): what would it take to convince you that “my sacred cow treatment” works? The challenge contains a thinly veiled accusation — no amount of evidence would convince you because you are a nasty skeptic.
There is a threshold of evidence that would convince me of just about anything, however. In fact, I have been convinced that many scientific claims are likely to be true — sufficiently convinced to act upon the conclusion that they are true. In medicine this means that I am convinced enough to use them as a basis for medical practice.
There are many functional differences between practitioners of SBM and those who accept claims and practices that we would consider to be pseudoscience or fraud, but I was recently struck by one particular such difference — where we set the threshold of evidence before accepting a claim.