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	<title>Comments on: An Influenza Recap: The End of the Second Wave</title>
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	<link>http://www.sciencebasedmedicine.org/?p=3029</link>
	<description>Exploring issues and controversies in the relationship between science and medicine</description>
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		<title>By: squirrelelite</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-40579</link>
		<dc:creator>squirrelelite</dc:creator>
		<pubDate>Sun, 24 Jan 2010 17:01:16 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-40579</guid>
		<description>Libby,
Thanks for coming to the influenza recap post to discuss influenza. While off topic comments can be useful or at least entertaining, it is usually best to stick to the topic at hand.
I will mostly ignore the “demonizing” question because I don’t want to spend the time right now to chase down the original post where you asked about evidence of effectiveness. I will merely note that asking for data is not demonizing. However, implying or suggesting that; because the data available lack the detail, accuracy and completeness that you wish; the product under discussion is therefore somehow inadequate could be construed as such. I apologize if this is not quite what you were getting at.
Keep in mind that the precision and accuracy of data always depend on time and money and the availability of other resources such as equipment and labor. Diagnosing that someone is sick with influenza or influenza like illness (ILI) is a relatively straight forward diagnosis, as is determining on a death certificate that they died from ILI or a related disease such as pneumonia. On the other hand, taking a genetic sample and determining the precise genotype of the virus so that we can accurately decide if it is the novel 2009 H1N1 strain or some other flu virus is a complex procedure that takes a lot of time and resources that simply are not available at the state health departments that conduct the tests. Probably it will be a lot quicker and easier in another ten years, but for right now, it’s not as easy as it looks in the CSI shows.
So, that leaves us with the data that are available and which Chris noted in his comment. There are some inherent estimates, assumptions, and uncertainties which we keep checking against reality and adjusting for. Here is what I have teased out from the sources Chris mentioned and perhaps a few others.
If you want carefully tested real data on whether the H1N1 vaccine does what it is supposed to (generate antibodies), here is an article about some published studies.
http://www.medicalnewstoday.com/articles/174147.php
The CDC estimates for 2009 flu that Chris linked to are good to keep up on.
The weekly update reports are also good to check.
http://www.cdc.gov/h1n1flu/update.htm
Approval of the H1N1 vaccines was announced on 15 Sep 2009, with initial availability projected for 5 Oct 2009.
Weekly percent of ILI cases peaked in most U.S. regions about weeks 41-42 (8 Oct-21 Oct 2009). Since then, there has been a sharp and mostly steady decline.
The following table shows how we have gone from initial restricted availability in early October to the current situation where the vaccine is available to just about anyone who wants to get it.
CDC Weekly Briefing Data
Date		Doses Available
7 Jan 2010	136 million
22 Dec 2009	111 million
10 Dec 2009	85 million
1 Dec 2009	70 million
20 Nov 2009	54.1 million
12 Nov 2009	41.6 million
3 Nov 2009	31.8 million
27 Oct 2009	22.4 million
16 Oct 2009	11.4 million
9 Oct 2009	6.8 million
1 Oct 2009	600,000 doses ordered
Here are the cumulative H1N1 Case Totals from April 2009 till the listed date, which Chris also referred to:
Date 		Cases		Hospitalizations		Deaths
17 Oct 2009	22 million	98,000			3900
14 Nov 2009	47 million	213,000		9820
12 Dec 2009	55 million	246,000		11,150
So, from 17 Oct to 14 Nov there were 115,000 hospitalizations and 5920 deaths from the H1N1 virus. 0.0237% of cases resulted in deaths.
From 14 Nov to 12 Dec, these numbers dropped to 33,000 hospitalizations and 1330 deaths. 0.0166% resulted in deaths.
Since 18-19% of the U.S. population has now suffered through the H1N1 flu and another 20% has gotten vaccinated, almost 40% are now protected in one way or another. Some of the drop in cases from Nov to Dec was undoubtedly due to normal flu case load variation and the eventual decline in the disease as more people become resistant. Some of it probably resulted from availability of the vaccine and 20% getting immunized. The details just aren’t there yet to separate the two effects, but we can hope they will be forthcoming.
Since there are four months left in the “normal” flu season, I have already gotten the seasonal flu shot and plan to get an H1N1 shot soon.</description>
		<content:encoded><![CDATA[<p>Libby,<br />
Thanks for coming to the influenza recap post to discuss influenza. While off topic comments can be useful or at least entertaining, it is usually best to stick to the topic at hand.<br />
I will mostly ignore the “demonizing” question because I don’t want to spend the time right now to chase down the original post where you asked about evidence of effectiveness. I will merely note that asking for data is not demonizing. However, implying or suggesting that; because the data available lack the detail, accuracy and completeness that you wish; the product under discussion is therefore somehow inadequate could be construed as such. I apologize if this is not quite what you were getting at.<br />
Keep in mind that the precision and accuracy of data always depend on time and money and the availability of other resources such as equipment and labor. Diagnosing that someone is sick with influenza or influenza like illness (ILI) is a relatively straight forward diagnosis, as is determining on a death certificate that they died from ILI or a related disease such as pneumonia. On the other hand, taking a genetic sample and determining the precise genotype of the virus so that we can accurately decide if it is the novel 2009 H1N1 strain or some other flu virus is a complex procedure that takes a lot of time and resources that simply are not available at the state health departments that conduct the tests. Probably it will be a lot quicker and easier in another ten years, but for right now, it’s not as easy as it looks in the CSI shows.<br />
So, that leaves us with the data that are available and which Chris noted in his comment. There are some inherent estimates, assumptions, and uncertainties which we keep checking against reality and adjusting for. Here is what I have teased out from the sources Chris mentioned and perhaps a few others.<br />
If you want carefully tested real data on whether the H1N1 vaccine does what it is supposed to (generate antibodies), here is an article about some published studies.<br />
<a href="http://www.medicalnewstoday.com/articles/174147.php" rel="nofollow">http://www.medicalnewstoday.com/articles/174147.php</a><br />
The CDC estimates for 2009 flu that Chris linked to are good to keep up on.<br />
The weekly update reports are also good to check.<br />
<a href="http://www.cdc.gov/h1n1flu/update.htm" rel="nofollow">http://www.cdc.gov/h1n1flu/update.htm</a><br />
Approval of the H1N1 vaccines was announced on 15 Sep 2009, with initial availability projected for 5 Oct 2009.<br />
Weekly percent of ILI cases peaked in most U.S. regions about weeks 41-42 (8 Oct-21 Oct 2009). Since then, there has been a sharp and mostly steady decline.<br />
The following table shows how we have gone from initial restricted availability in early October to the current situation where the vaccine is available to just about anyone who wants to get it.<br />
CDC Weekly Briefing Data<br />
Date		Doses Available<br />
7 Jan 2010	136 million<br />
22 Dec 2009	111 million<br />
10 Dec 2009	85 million<br />
1 Dec 2009	70 million<br />
20 Nov 2009	54.1 million<br />
12 Nov 2009	41.6 million<br />
3 Nov 2009	31.8 million<br />
27 Oct 2009	22.4 million<br />
16 Oct 2009	11.4 million<br />
9 Oct 2009	6.8 million<br />
1 Oct 2009	600,000 doses ordered<br />
Here are the cumulative H1N1 Case Totals from April 2009 till the listed date, which Chris also referred to:<br />
Date 		Cases		Hospitalizations		Deaths<br />
17 Oct 2009	22 million	98,000			3900<br />
14 Nov 2009	47 million	213,000		9820<br />
12 Dec 2009	55 million	246,000		11,150<br />
So, from 17 Oct to 14 Nov there were 115,000 hospitalizations and 5920 deaths from the H1N1 virus. 0.0237% of cases resulted in deaths.<br />
From 14 Nov to 12 Dec, these numbers dropped to 33,000 hospitalizations and 1330 deaths. 0.0166% resulted in deaths.<br />
Since 18-19% of the U.S. population has now suffered through the H1N1 flu and another 20% has gotten vaccinated, almost 40% are now protected in one way or another. Some of the drop in cases from Nov to Dec was undoubtedly due to normal flu case load variation and the eventual decline in the disease as more people become resistant. Some of it probably resulted from availability of the vaccine and 20% getting immunized. The details just aren’t there yet to separate the two effects, but we can hope they will be forthcoming.<br />
Since there are four months left in the “normal” flu season, I have already gotten the seasonal flu shot and plan to get an H1N1 shot soon.</p>
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		<title>By: Perky Skeptic</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-40571</link>
		<dc:creator>Perky Skeptic</dc:creator>
		<pubDate>Sun, 24 Jan 2010 15:31:38 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-40571</guid>
		<description>What is killing me (omgroflol) is that where I live, the Walgreens chain has had plenty of H1N1 vaccine throughout the season, yet neither my own doctor&#039;s office in a major metropolitan medical clinic or my son&#039;s pediatrician&#039;s office had ANY, except for baby-sized doses. Sheesh!

What&#039;s the deal there? Does the CDC figure that more of it gets to the public if it&#039;s available in drug stores rather than in various doctors&#039; offices? (They might be right-- I&#039;m just curious.)</description>
		<content:encoded><![CDATA[<p>What is killing me (omgroflol) is that where I live, the Walgreens chain has had plenty of H1N1 vaccine throughout the season, yet neither my own doctor&#8217;s office in a major metropolitan medical clinic or my son&#8217;s pediatrician&#8217;s office had ANY, except for baby-sized doses. Sheesh!</p>
<p>What&#8217;s the deal there? Does the CDC figure that more of it gets to the public if it&#8217;s available in drug stores rather than in various doctors&#8217; offices? (They might be right&#8211; I&#8217;m just curious.)</p>
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		<title>By: libby</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-40562</link>
		<dc:creator>libby</dc:creator>
		<pubDate>Sun, 24 Jan 2010 12:58:57 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-40562</guid>
		<description>Oh and Chris, one other point.

Thanks for quoting me and then EXcluding the correction of my post so that it actually made sense.

(Of those who died from the H1N1 virus) HOW MANY WERE VACCINATED?

That was my complete sentence, if the truth has any meaning to you. 

It&#039;s amazing how such a simple question has created such a frenetic, nervous response.</description>
		<content:encoded><![CDATA[<p>Oh and Chris, one other point.</p>
<p>Thanks for quoting me and then EXcluding the correction of my post so that it actually made sense.</p>
<p>(Of those who died from the H1N1 virus) HOW MANY WERE VACCINATED?</p>
<p>That was my complete sentence, if the truth has any meaning to you. </p>
<p>It&#8217;s amazing how such a simple question has created such a frenetic, nervous response.</p>
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		<title>By: libby</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-40548</link>
		<dc:creator>libby</dc:creator>
		<pubDate>Sun, 24 Jan 2010 07:04:02 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-40548</guid>
		<description>I find Chris&#039;s personal attacks quite risible if for nothing other than they are so clumsy.</description>
		<content:encoded><![CDATA[<p>I find Chris&#8217;s personal attacks quite risible if for nothing other than they are so clumsy.</p>
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		<title>By: libby</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-40546</link>
		<dc:creator>libby</dc:creator>
		<pubDate>Sun, 24 Jan 2010 06:41:07 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-40546</guid>
		<description>Chris:

You claimed I was demonizing the H1N1 vaccine by asking for evidence of its effectiveness. I never knew that asking for evidence could be seen as demonizing, especially on a site with &quot;science&quot; in its name.

And to claim there isn&#039;t enough data is remarkable. If 2 die from H1N1, you look at their vaccine records. If 10 die, you look at their vaccine records. If 100 die, you look at their vaccine records, etc, etc. We&#039;re only talking about deaths from H1N1, nothing else.  

The more that die, the more accurate your ratio. This is just numbers.

Chris states: &quot;most of the deaths occurred before the vaccine was available&quot; is totally irrelevant because you simply limit the scope of your analysis to AFTER the introduction of the vaccine, or any time period you want for that matter that will give you the best data. 

Someone else claimed there was a privacy issue on corpses (another astounding concept), but in any case, the numbers and ratios would not have to show names.</description>
		<content:encoded><![CDATA[<p>Chris:</p>
<p>You claimed I was demonizing the H1N1 vaccine by asking for evidence of its effectiveness. I never knew that asking for evidence could be seen as demonizing, especially on a site with &#8220;science&#8221; in its name.</p>
<p>And to claim there isn&#8217;t enough data is remarkable. If 2 die from H1N1, you look at their vaccine records. If 10 die, you look at their vaccine records. If 100 die, you look at their vaccine records, etc, etc. We&#8217;re only talking about deaths from H1N1, nothing else.  </p>
<p>The more that die, the more accurate your ratio. This is just numbers.</p>
<p>Chris states: &#8220;most of the deaths occurred before the vaccine was available&#8221; is totally irrelevant because you simply limit the scope of your analysis to AFTER the introduction of the vaccine, or any time period you want for that matter that will give you the best data. </p>
<p>Someone else claimed there was a privacy issue on corpses (another astounding concept), but in any case, the numbers and ratios would not have to show names.</p>
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		<title>By: Chris</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-40311</link>
		<dc:creator>Chris</dc:creator>
		<pubDate>Thu, 21 Jan 2010 19:01:07 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-40311</guid>
		<description>libby (from elsewhere, since it is off topic there): &lt;blockquote&gt;The solid hard evidence that confirms the effectiveness of the vaccine is this: of those who died from the H1N1 virus, We’re not evaluating trends, we’re not making a “good guess”, we’re not having to deal with the natural fluctuations of a disease as it moves through a population, nor the fact that a good percentage of people didn’t get the vaccine. It’s pure numbers.&lt;/blockquote&gt;

&lt;blockquote&gt;Furthermore this evidence is very easy to attain, since medical experts would have vaccinations records of all those how died. Easy info at our fingertips, except for one thing……I can’t find it.&lt;/blockquote&gt;

Since only 20% of the entire population has been vaccinated, and most of the deaths occurred before the vaccine was available, the answer is that it is too early.

Look at the data here: http://www.cdc.gov/h1n1flu/estimates_2009_h1n1.htm

Read this paragraph:  &lt;blockquote&gt;CDC estimated that between about 7,070 and 13,930 2009 H1N1-related deaths occurred between April and November 14, 2009. The mid-level in this range was about 9,820 2009 H1N1-related deaths.&lt;/blockquote&gt;

Assume that no one who got the flu had been vaccinated, and remember this is a key concept:  &lt;b&gt;because there was &lt;i&gt;no&lt;/i&gt; vaccine.

Now read this paragraph:  &lt;blockquote&gt;CDC estimates that between about 7,880 and 16,460 2009 H1N1-related deaths occurred between April and December 12, 2009. The mid-level in this range is about 11,160 2009 H1N1-related deaths.&lt;/blockquote&gt;

Now note that the vaccine had barely been available, but to only select groups.  As of yet (I repeat) only 20% of the USA has been vaccinated.  So it is a fair &lt;i&gt;guess&lt;/i&gt; that the additional 1300 deaths (using the mid-level &lt;i&gt;estimate&lt;/i&gt;) were &lt;b&gt;not&lt;/b&gt; vaccinated.

So the answer to why you cannot find the information you want (for some unknown reason) is because of &lt;b&gt;insufficient data&lt;/b&gt;.   

Since the H1N1 vaccine is a monovalent, and it is designed for a specific virus (no guessing required like the regular bivalent flu vaccine) there are estimates that it is at least 90% effective (remember not everyone will respond to a vaccine, no matter how good it is, due to genetic variability).  For more information on influenza, including a Virology 101 course checkout http://www.virology.ws/.</description>
		<content:encoded><![CDATA[<p>libby (from elsewhere, since it is off topic there):<br />
<blockquote>The solid hard evidence that confirms the effectiveness of the vaccine is this: of those who died from the H1N1 virus, We’re not evaluating trends, we’re not making a “good guess”, we’re not having to deal with the natural fluctuations of a disease as it moves through a population, nor the fact that a good percentage of people didn’t get the vaccine. It’s pure numbers.</p></blockquote>
<blockquote><p>Furthermore this evidence is very easy to attain, since medical experts would have vaccinations records of all those how died. Easy info at our fingertips, except for one thing……I can’t find it.</p></blockquote>
<p>Since only 20% of the entire population has been vaccinated, and most of the deaths occurred before the vaccine was available, the answer is that it is too early.</p>
<p>Look at the data here: <a href="http://www.cdc.gov/h1n1flu/estimates_2009_h1n1.htm" rel="nofollow">http://www.cdc.gov/h1n1flu/estimates_2009_h1n1.htm</a></p>
<p>Read this paragraph:<br />
<blockquote>CDC estimated that between about 7,070 and 13,930 2009 H1N1-related deaths occurred between April and November 14, 2009. The mid-level in this range was about 9,820 2009 H1N1-related deaths.</p></blockquote>
<p>Assume that no one who got the flu had been vaccinated, and remember this is a key concept:  <b>because there was <i>no</i> vaccine.</p>
<p>Now read this paragraph:<br />
<blockquote>CDC estimates that between about 7,880 and 16,460 2009 H1N1-related deaths occurred between April and December 12, 2009. The mid-level in this range is about 11,160 2009 H1N1-related deaths.</p></blockquote>
<p>Now note that the vaccine had barely been available, but to only select groups.  As of yet (I repeat) only 20% of the USA has been vaccinated.  So it is a fair <i>guess</i> that the additional 1300 deaths (using the mid-level <i>estimate</i>) were </b><b>not</b> vaccinated.</p>
<p>So the answer to why you cannot find the information you want (for some unknown reason) is because of <b>insufficient data</b>.   </p>
<p>Since the H1N1 vaccine is a monovalent, and it is designed for a specific virus (no guessing required like the regular bivalent flu vaccine) there are estimates that it is at least 90% effective (remember not everyone will respond to a vaccine, no matter how good it is, due to genetic variability).  For more information on influenza, including a Virology 101 course checkout <a href="http://www.virology.ws/." rel="nofollow">http://www.virology.ws/.</a></p>
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		<title>By: Chris</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-40253</link>
		<dc:creator>Chris</dc:creator>
		<pubDate>Thu, 21 Jan 2010 08:54:02 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-40253</guid>
		<description>My question is why is &quot;libby&quot; so intent on demonizing the influenza vaccine?  She has been asking &quot;Out of all the deaths from H1N1 in the US, how many were unvaccinated and how many vaccinated.&quot; --- and yet missed posting that question here.

She did not seem to understand that there were more months between April 2009 (when the count of deaths started) to November 2009 (when the vaccine was available), than between November 2009 and January 2010.  So she did not like my answer that the deaths before November were of people who were not vaccinated (and for those who are slow:  it is because there was no vaccine), and then estimate the rest.  At the present (late Jan. 2010) the CDC has reported that 20% of the USA population has been vaccinated:
http://www.reuters.com/article/idUSN1521475420100115

She also claimed some great stuff with Cuba and vaccine, claiming the literature was only available in Spanish.  Unfortunately she did not count on Dr. Harriet Hall being fluent in Spanish.  Apparently Cuba is not immune to flu:
http://www.laht.com/article.asp?ArticleId=349456&amp;CategoryId=14510</description>
		<content:encoded><![CDATA[<p>My question is why is &#8220;libby&#8221; so intent on demonizing the influenza vaccine?  She has been asking &#8220;Out of all the deaths from H1N1 in the US, how many were unvaccinated and how many vaccinated.&#8221; &#8212; and yet missed posting that question here.</p>
<p>She did not seem to understand that there were more months between April 2009 (when the count of deaths started) to November 2009 (when the vaccine was available), than between November 2009 and January 2010.  So she did not like my answer that the deaths before November were of people who were not vaccinated (and for those who are slow:  it is because there was no vaccine), and then estimate the rest.  At the present (late Jan. 2010) the CDC has reported that 20% of the USA population has been vaccinated:<br />
<a href="http://www.reuters.com/article/idUSN1521475420100115" rel="nofollow">http://www.reuters.com/article/idUSN1521475420100115</a></p>
<p>She also claimed some great stuff with Cuba and vaccine, claiming the literature was only available in Spanish.  Unfortunately she did not count on Dr. Harriet Hall being fluent in Spanish.  Apparently Cuba is not immune to flu:<br />
<a href="http://www.laht.com/article.asp?ArticleId=349456&amp;CategoryId=14510" rel="nofollow">http://www.laht.com/article.asp?ArticleId=349456&amp;CategoryId=14510</a></p>
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		<title>By: wales</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-38351</link>
		<dc:creator>wales</dc:creator>
		<pubDate>Thu, 31 Dec 2009 23:15:24 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-38351</guid>
		<description>Here&#039;s one person who has not been vaccinated, and wins the irony of the year award.  Buried toward the end of a December 29, 2009 BBC article titled “Swine flu virus &#039;could still mutate&#039; WHO warns” is this somewhat mysterious line regarding WHO director Margaret Chan “However she admitted she had not yet had a vaccine but said she would have it soon”.

Huh?  I had to do a doubletake.  December 29 and the WHO director still hasn’t been vaccinated for H1N1?  What does she mean by “soon”?  Doesn&#039;t she heed her own warning about viral mutation?  Surely the WHO director would have been given top priority, had she chosen to become vaccinated.  Doesn’t she care about her responsibility to the world as WHO director, and her responsibility to prevent spread of H1N1 to her co-workers, family and friends?  Is she some sort of vaccine “free-rider” relying on herd immunity?  

http://news.bbc.co.uk/2/hi/health/8434273.stm</description>
		<content:encoded><![CDATA[<p>Here&#8217;s one person who has not been vaccinated, and wins the irony of the year award.  Buried toward the end of a December 29, 2009 BBC article titled “Swine flu virus &#8216;could still mutate&#8217; WHO warns” is this somewhat mysterious line regarding WHO director Margaret Chan “However she admitted she had not yet had a vaccine but said she would have it soon”.</p>
<p>Huh?  I had to do a doubletake.  December 29 and the WHO director still hasn’t been vaccinated for H1N1?  What does she mean by “soon”?  Doesn&#8217;t she heed her own warning about viral mutation?  Surely the WHO director would have been given top priority, had she chosen to become vaccinated.  Doesn’t she care about her responsibility to the world as WHO director, and her responsibility to prevent spread of H1N1 to her co-workers, family and friends?  Is she some sort of vaccine “free-rider” relying on herd immunity?  </p>
<p><a href="http://news.bbc.co.uk/2/hi/health/8434273.stm" rel="nofollow">http://news.bbc.co.uk/2/hi/health/8434273.stm</a></p>
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		<title>By: Chrtowsky</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-37507</link>
		<dc:creator>Chrtowsky</dc:creator>
		<pubDate>Sat, 19 Dec 2009 17:33:03 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-37507</guid>
		<description>Does anybody know how many people were vaccinated to date in the US?</description>
		<content:encoded><![CDATA[<p>Does anybody know how many people were vaccinated to date in the US?</p>
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		<title>By: Zoe237</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-37320</link>
		<dc:creator>Zoe237</dc:creator>
		<pubDate>Thu, 17 Dec 2009 19:27:11 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-37320</guid>
		<description>I have to agree with some previous posters. The story in this case isn&#039;t so much with the media or the anti-vaxers. It&#039;s about the fact that it IS the end of the second wave and millions are still waiting for the vaccine.

I am curious though that it seem like a ton of HCP are not getting the vaccine. My husband did, but a lot of his collegues are refusing it, and advocating it only for children or immunocompromised people.</description>
		<content:encoded><![CDATA[<p>I have to agree with some previous posters. The story in this case isn&#8217;t so much with the media or the anti-vaxers. It&#8217;s about the fact that it IS the end of the second wave and millions are still waiting for the vaccine.</p>
<p>I am curious though that it seem like a ton of HCP are not getting the vaccine. My husband did, but a lot of his collegues are refusing it, and advocating it only for children or immunocompromised people.</p>
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		<title>By: Calli Arcale</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-37315</link>
		<dc:creator>Calli Arcale</dc:creator>
		<pubDate>Thu, 17 Dec 2009 19:11:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-37315</guid>
		<description>I was in the emergency room with severe chest pain two days after receiving the 2009 H1N1 vaccine!  EEK!!!

I definitely will not be submitting a report to VAERS, though, as the cause of my chest pain was quickly determined to be esophageal spasm -- my acid reflux disease (which I&#039;ve battled for many years, and which runs strongly in my family) has apparently kicked itself up a notch.  That, and I probably shouldn&#039;t have had all that yummy, delicious rommegrot.  :-P  I&#039;ll be getting an endoscopy next month, as it&#039;s suspected that I&#039;ve developed another stricture.  Yay.

Still, if I were an anti-vaxxer, I&#039;m sure I would&#039;ve believed there was some kind of a connection, despite the fact that I&#039;ve had gradually increasing episodes of epigastric pain over the last month, leading up to this particularly severe episode.</description>
		<content:encoded><![CDATA[<p>I was in the emergency room with severe chest pain two days after receiving the 2009 H1N1 vaccine!  EEK!!!</p>
<p>I definitely will not be submitting a report to VAERS, though, as the cause of my chest pain was quickly determined to be esophageal spasm &#8212; my acid reflux disease (which I&#8217;ve battled for many years, and which runs strongly in my family) has apparently kicked itself up a notch.  That, and I probably shouldn&#8217;t have had all that yummy, delicious rommegrot.  <img src='http://www.sciencebasedmedicine.org/wp-includes/images/smilies/icon_razz.gif' alt=':-P' class='wp-smiley' />   I&#8217;ll be getting an endoscopy next month, as it&#8217;s suspected that I&#8217;ve developed another stricture.  Yay.</p>
<p>Still, if I were an anti-vaxxer, I&#8217;m sure I would&#8217;ve believed there was some kind of a connection, despite the fact that I&#8217;ve had gradually increasing episodes of epigastric pain over the last month, leading up to this particularly severe episode.</p>
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		<title>By: Influenza: The Second Wave &#171; College Health</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-37190</link>
		<dc:creator>Influenza: The Second Wave &#171; College Health</dc:creator>
		<pubDate>Tue, 15 Dec 2009 15:54:28 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-37190</guid>
		<description>[...] Influenza: The Second Wave [...]</description>
		<content:encoded><![CDATA[<p>[...] Influenza: The Second Wave [...]</p>
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		<title>By: Deetee</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-37114</link>
		<dc:creator>Deetee</dc:creator>
		<pubDate>Mon, 14 Dec 2009 08:29:54 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-37114</guid>
		<description>@winddriven - you ask &quot;Doesn’t herd immunity require something on the order of 90% immunization?&quot;

That depends on the reproductive number (R0) of the infection you are dealing with. This indicates the number of people a case is likely to infect. For measles it is around 15, but for flu it seems to be between 1.5 and 2. An infection with a very low R0 will not spread widely, meaning that you need fewer people in the herd to be &quot;immune&quot; before it grinds to a complete halt.

To estimate how many of the population need to be immune (vaccinated or recovered from infection) in order to negate the risk of epidemic spread, you can use the R0 in the following calculation:

Proportion of population required to be immune = 1-1/R0.

For measles this is 1-1/15, which is 0.933 (or 93%, which is why the aim is to achieve this amount of vaccine uptake to get herd immunity). For flu it is between 1-1/1.5 and 1-1/2, or between 33% and 50%.

So it is possible that with only 1/3 to 1/2 of the herd being immune through vaccination or having had flu, that onward transmission would fizzle out. There are many other factors that could influence this however, and things are not always that simple (but it is still clear that you will not need 90% vaccine uptake to eliminate flu transmission)</description>
		<content:encoded><![CDATA[<p>@winddriven &#8211; you ask &#8220;Doesn’t herd immunity require something on the order of 90% immunization?&#8221;</p>
<p>That depends on the reproductive number (R0) of the infection you are dealing with. This indicates the number of people a case is likely to infect. For measles it is around 15, but for flu it seems to be between 1.5 and 2. An infection with a very low R0 will not spread widely, meaning that you need fewer people in the herd to be &#8220;immune&#8221; before it grinds to a complete halt.</p>
<p>To estimate how many of the population need to be immune (vaccinated or recovered from infection) in order to negate the risk of epidemic spread, you can use the R0 in the following calculation:</p>
<p>Proportion of population required to be immune = 1-1/R0.</p>
<p>For measles this is 1-1/15, which is 0.933 (or 93%, which is why the aim is to achieve this amount of vaccine uptake to get herd immunity). For flu it is between 1-1/1.5 and 1-1/2, or between 33% and 50%.</p>
<p>So it is possible that with only 1/3 to 1/2 of the herd being immune through vaccination or having had flu, that onward transmission would fizzle out. There are many other factors that could influence this however, and things are not always that simple (but it is still clear that you will not need 90% vaccine uptake to eliminate flu transmission)</p>
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		<title>By: halincoh</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-37057</link>
		<dc:creator>halincoh</dc:creator>
		<pubDate>Sun, 13 Dec 2009 05:52:37 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-37057</guid>
		<description>Nicely done as always. I finally get to receive my dose on Monday the 14th. People have wondered if they should still get the vaccine as the rates ( here in Maine ) decline. Protection against a possible &quot;third wave&quot; is a definite strategy as to answering them in the affirmative. Thanks.</description>
		<content:encoded><![CDATA[<p>Nicely done as always. I finally get to receive my dose on Monday the 14th. People have wondered if they should still get the vaccine as the rates ( here in Maine ) decline. Protection against a possible &#8220;third wave&#8221; is a definite strategy as to answering them in the affirmative. Thanks.</p>
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		<title>By: SF Mom and Scientist</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-36965</link>
		<dc:creator>SF Mom and Scientist</dc:creator>
		<pubDate>Fri, 11 Dec 2009 17:39:46 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-36965</guid>
		<description>windriven took the words out of my mouth. The biggest topic of discussion among our group was where the $%^$^% to get this vaccine. I was able to get my son both his shots before Thanksgiving and I felt like I won the lottery. The one thing I am hoping will come out of this is the development and acceptance of faster methods of vaccine testing/production. (I know this will give more &quot;ammo&quot; to anti-vaccine groups, but seeing as how they will never give up anyway, it is worth pursuing.)</description>
		<content:encoded><![CDATA[<p>windriven took the words out of my mouth. The biggest topic of discussion among our group was where the $%^$^% to get this vaccine. I was able to get my son both his shots before Thanksgiving and I felt like I won the lottery. The one thing I am hoping will come out of this is the development and acceptance of faster methods of vaccine testing/production. (I know this will give more &#8220;ammo&#8221; to anti-vaccine groups, but seeing as how they will never give up anyway, it is worth pursuing.)</p>
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		<title>By: edgar</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-36963</link>
		<dc:creator>edgar</dc:creator>
		<pubDate>Fri, 11 Dec 2009 16:35:35 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-36963</guid>
		<description>Generally most AI/AN communities are OK to all vaccines, although they have some of the same concerns (too many at once, etc)  some Tribes do delayed schedule. I know of one Tribe that will not give polio, I have heard various reasons for this.  

I do not have info on the availability, but generally it is distributed through CDC to Tribes that offer vax in their clinics, and through the states through some that don&#039;t (some Tribes are so small that their clinics and mostly referral only)

However, there is something called GPRA, and it is a publically available data set, where you can look up vax coverage rates.  Although interpret with caution, especially with vax, as low vax rates may be in indication of tracking issues and not coverage (i.e. a parent may go tot he health department for 1 or more vax, and that info does not get back into the system).
As for being consider high risk, i think in practice they generally are, what with the high rate of diabetes and other chronic illness.</description>
		<content:encoded><![CDATA[<p>Generally most AI/AN communities are OK to all vaccines, although they have some of the same concerns (too many at once, etc)  some Tribes do delayed schedule. I know of one Tribe that will not give polio, I have heard various reasons for this.  </p>
<p>I do not have info on the availability, but generally it is distributed through CDC to Tribes that offer vax in their clinics, and through the states through some that don&#8217;t (some Tribes are so small that their clinics and mostly referral only)</p>
<p>However, there is something called GPRA, and it is a publically available data set, where you can look up vax coverage rates.  Although interpret with caution, especially with vax, as low vax rates may be in indication of tracking issues and not coverage (i.e. a parent may go tot he health department for 1 or more vax, and that info does not get back into the system).<br />
As for being consider high risk, i think in practice they generally are, what with the high rate of diabetes and other chronic illness.</p>
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		<title>By: windriven</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-36962</link>
		<dc:creator>windriven</dc:creator>
		<pubDate>Fri, 11 Dec 2009 16:22:59 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-36962</guid>
		<description>Interesting article edgar.  Do you have any information on cultural receptivity to vaccination in the AI/AN communities?  Do you have any information on the availability of the vaccine in those communities?  And wouldn&#039;t this suggest that AI/AN populations should be considered &#039;high risk&#039; populations in the event of future influenza outbreaks?</description>
		<content:encoded><![CDATA[<p>Interesting article edgar.  Do you have any information on cultural receptivity to vaccination in the AI/AN communities?  Do you have any information on the availability of the vaccine in those communities?  And wouldn&#8217;t this suggest that AI/AN populations should be considered &#8216;high risk&#8217; populations in the event of future influenza outbreaks?</p>
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		<title>By: Todd W.</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-36960</link>
		<dc:creator>Todd W.</dc:creator>
		<pubDate>Fri, 11 Dec 2009 15:54:21 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-36960</guid>
		<description>Dr. Albietz,

Thank you for yet another great post on this topic.  Good info to have available.  It is wonderful that there is a source for this information, like SBM, since the media tends to ignore or misstate the issues.</description>
		<content:encoded><![CDATA[<p>Dr. Albietz,</p>
<p>Thank you for yet another great post on this topic.  Good info to have available.  It is wonderful that there is a source for this information, like SBM, since the media tends to ignore or misstate the issues.</p>
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		<title>By: edgar</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-36959</link>
		<dc:creator>edgar</dc:creator>
		<pubDate>Fri, 11 Dec 2009 14:23:34 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-36959</guid>
		<description>Interesting MMWR article on mortality and sub-populations
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5848a1.htm</description>
		<content:encoded><![CDATA[<p>Interesting MMWR article on mortality and sub-populations<br />
<a href="http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5848a1.htm" rel="nofollow">http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5848a1.htm</a></p>
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		<title>By: windriven</title>
		<link>http://www.sciencebasedmedicine.org/?p=3029&#038;cpage=1#comment-36952</link>
		<dc:creator>windriven</dc:creator>
		<pubDate>Fri, 11 Dec 2009 13:08:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.sciencebasedmedicine.org/?p=3029#comment-36952</guid>
		<description>&quot;Two topics have dominated the conversation: the safety of the 2009 H1N1 influenza vaccine, and the actual severity of the 2009 H1N1 infection. &quot;

I would like to add a third topic: the inability to get the vaccine.  I for one am still waiting.  Doesn&#039;t herd immunity require something on the order of 90% immunization?</description>
		<content:encoded><![CDATA[<p>&#8220;Two topics have dominated the conversation: the safety of the 2009 H1N1 influenza vaccine, and the actual severity of the 2009 H1N1 infection. &#8221;</p>
<p>I would like to add a third topic: the inability to get the vaccine.  I for one am still waiting.  Doesn&#8217;t herd immunity require something on the order of 90% immunization?</p>
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