Results for: Comparative Effectiveness Research

Comparative Clinical Effectiveness Research: Good News In Shades Of Gray

When I first heard about the new emphasis on comparative clinical effectiveness research (CCER) in Obama’s economic stimulus bill I thought, “Thank goodness! Maybe now science will truly regain its rightful place and we’ll end the CAM, ‘me-too’ drug, and excessive-use-of-technology madness that is wasting so much money in healthcare.” In fact, I was so excited about the new administration’s apparent interest...

/ February 19, 2009

The Pollyanna Phenomenon and Non-Inferiority: How Our Experience (and Research) Can Lead to Poor Treatment Choices

Pollyanna, a popular children’s book written in 1913 by Eleanor H. Porter, introduced the world to one of the most optimistic fictional characters ever created. She always saw the good in people and her approach to life frequently involved playing “The Glad Game”, where she attempted to find something to appreciate in every situation no matter how unfortunate. She was glad about...

/ February 14, 2014

Integrating patient experience into research and clinical medicine: Towards true “personalized medicine”

We advocate science-based medicine (SBM) on this blog. However, from time to time, I feel it necessary to point out that science-based medicine is not the same thing as turning medicine into a science. Rather, we argue that what we do as clinicians should be based in science. This is not a distinction without a difference. If we were practicing pure science,...

/ November 8, 2010

Cancer research: Going for the bunt versus swinging for the fences

A couple of weeks ago, our resident skeptical medical student Tim Kreider wrote an excellent article about an op-ed in NEWSWEEK by science correspondent Sharon Begley, in which he pointed out many misconceptions she had regarding basic science versus translational research, journal impact factors, and how journals actually determine what they will publish. Basically, her thesis rested on little more than a...

/ June 29, 2009

Is translational research impaired by an emphasis on basic science?

Sharon Begley, the Science Editor for Newsweek, wrote about translational research in the latest issue, and the tone of the essay reminded me of Begley’s previous piece on comparative-effectiveness research. Being an MD/PhD student (just defended!) I am very interested in the process of communicating “from bench to bedside.” New to science as I may be, I found Begley’s arguments to be overly...

/ June 12, 2009

The effort of integrative medicine advocates to co-opt the opioid crisis to claim non pharmacological treatments for pain as solely theirs continues apace

Last week, I wrote about how advocates for quackery were trying, and succeeding, at persuading state Medicaid agencies to pay for acupuncture for pain. This week, I discuss how they are promoting the integration of quackery with medicine. In this case, they are promoting a white paper and trying to influence the AHRQ.

/ January 29, 2018

Tai Chi versus physical therapy for osteoarthritis of the knee: How CAM “rebranding” works

“Complementary and alternative medicine” (CAM), now more frequently referred to as “integrative medicine” by its proponents, consists of a hodge-podge of largely unrelated treatments that range from seemingly reasonable (e.g., diet and exercise) to pure quackery (e.g., acupuncture, reiki and other “energy medicine”) that CAM proponents are trying furiously to “integrate” as coequals into science-based medicine. They do this because they have...

/ May 23, 2016

The hijacking of evidence-based medicine

A hero of the blog, John Ioannidis, worries that evidence-based medicine has been hijacked, and when Ioannidis says something we at SBM listen. But has EBM been "hijacked"?

/ March 21, 2016

Choosing Wisely: Changing medical practice is hard

One of the hardest things to do in medicine is to change practice in the face of scientific evidence that what you're doing isn't working. Quacks never change, but medicine does. The change might be slower and messier than we would like, but change does happen. Choosing Wisely is an initiative designed to bring about change by discouraging the use of interventions...

/ October 19, 2015

Should physicians and managed care organizations offer homeopathy?

Anyone who reads Science-Based Medicine on even a semi-regular basis will know our collective opinion of homeopathy. Basically, at its core, homeopathy is pure quackery. I don’t care if it’s repetitive to say this yet again because it can’t be emphasized enough times that homeopathy is The One Quackery To Rule Them All. OK, there are others that compete for that title,...

/ July 20, 2015