Results for: bayesian
Evidence-based medicine vs. basic science in medical school
Last week Dr. Vinay Prasad wrote a Substack arguing that medical students should learn the principles of evidence-based medicine before basic science.This is a recipe for amplifying the main flaw in EBM that science-based medicine was meant to correct, and Dr. Prasad's arguments would have been right at home on an integrative medicine blog. [Note ADDENDUM.]
Aromatase inhibitors and acupuncture in breast cancer: Spinning a negative study, four years later
Four years ago, I wrote about an essentially negative study looking at whether acupuncture could alleviate joint pain caused by aromatase inhibitors, a common treatment for estrogen-sensitive breast cancer. The study's back, and it doesn't look any more positive.
But Is It Real?
Why we need more science in medicine.
Peer review fail: Vaccine publishes antivax propaganda disguised as “reanalyses” of Pfizer and Moderna COVID-19 vaccine clinical trial data
In order portray COVID-19 vaccines as dangerous, Peter Doshi has now managed to get poorly designed and performed "reanalyses" of the clinical trial data used by the FDA to grant emergency use approval of the Pfizer and Moderna vaccines published in two reputable journals, The BMJ and Vaccine? What happened?
Medical debt vs. universal health insurance: The interface between SBM and policy
This blog has long argued that the best medicine is science-based medicine (SBM). The problem is that in the US SBM is often not accessible, except at ruinous cost, which is why I argue that we have to broaden our definition of SBM to include the systems that deliver it and pay for it.
Is There a Replication Crisis?
The true causes and implications of the replication problem in science.
Science-based medicine isn’t just for CAM. The case of ivermectin shows that it never was.
Another large randomized controlled trial for ivermectin showed no efficacy for the early treatment of COVID-19. This is not a surprise to science-based medicine advocates. Here's why the story of ivermectin shows that SBM isn't just for "complementary and alternative medicine" (CAM) —and never was.
Ivermectin is the new hydroxychloroquine, take 6: Incompetence and fraud everywhere!
Ivermectin is the new hydroxychloroquine, a drug repurposed for COVID-19 that almost certainly doesn't work but is still being touted as a "miracle cure" by quacks, grifters, and political ideologues. Are the data supporting it all fraud?
Ivermectin is the new hydroxychloroquine, take 4: Bret Weinstein misrepresents meta-analyses
Evolutionary biologist turned podcaster Bret Weinstein has promoted the anthelmintic drug ivermectin as a highly effective treatment for COVID-19 based on a massive misunderstanding of a meta-analysis. Here, we correct this misunderstanding and explain why ivermectin is unlikely to be effective against COVID-19.
Ivermectin is the new hydroxychloroquine, take 3: Conspiracy theories vs. science
Last month, I discussed why ivermectin is the new hydroxychloroquine:, basically a “miracle cure” that isn’t. Since then, conspiracy theories about its being "suppressed" have continued to bump heads with the science showing that, at the very best, evidence for its efficacy is very weak and, at the worst, the drug is useless.