Whipworms in the intestine. Click to enlarge.
Humans evolved in an environment where they were exposed to animals, dirt, and a variety of pathogens and parasites. Our immune systems evolved to cope with that environment. Now most of us live in a different environment, with safe drinking water, flush toilets, food inspection, immunizations, and public sanitation. This means that we are far less likely than our ancestors to die of infectious diseases or to harbor intestinal worms. But it seems that the cleaner we get, the more likely we are to suffer from allergies and autoimmune diseases. One hypothesis is that our immune systems evolved to require early challenges by parasites and pathogens in order to develop properly. A hygienic environment fails to give our immune system the exercise it needs, resulting in imbalances and malfunctions.
The hygiene hypothesis was first proposed to explain observations like these:
- Hay fever and allergies were less common in large families where children were presumably exposed to more infections through their siblings.
- Polio attack rates were higher in high socioeconomic groups than in lower ones.
- Allergies and many other diseases were less common in the developing world.
Investigation of these and other phenomena is contributing to a better understanding of the immune system, which is a good thing. At the same time, it has led some people to deliberately infect themselves with intestinal worms in an attempt to cure their allergies and autoimmune diseases, which may not be such a good thing. These treatments are far from ready for prime time, are risky, and they have a high yuck factor. The very idea of deliberately infecting yourself with worms is unpalatable, and finding wiggly live creatures in your stool or passing a 20 foot tapeworm are not generally considered to be pleasant experiences. (more…)
A stay-at-home mom recently e-mailed me. She is a former CAM user who once treated her infant’s colic with homeopathy but has since seen the light and is now thinking skeptically. She asked that I look into the dōTERRA company, seller of essential oils: concentrated extracts distilled from plants, containing the “essence” or distinctive odor of the plant. She said:
…moms, well educated and seemingly rational moms, will believe anything. This isn’t a big deal if we are talking about sugar pills trying to cure crying that has no cause. However, I recently attended a dōTERRA “talk” (aka pressure to buy) about how essential oils can cure everything and anything, including one woman’s mother’s skin cancer. I didn’t want to offend this mom by calling her a quack, so I walked away spending 60 bucks on oils to be polite (this was the least amount I could spend and I used these oils to make my home smell nice, even though they were intended to solve all sorts of skin and digestive problems. I didn’t want to use them without knowing if they actually worked).
Instead of stressing the aromas, the focus was on the need to spend hundreds of dollars on these products to keep your family healthy. A handout showed how you could replace everything in your medicine cabinet with an essential oil alternative. She said:
The reps talked about how conventional medicine failed them and how they never go to the doctor anymore because the oils are a better cure.
I donated a knit afghan to the auction by Skeptics for the Protection of Cancer Patients. I made it myself. Proceeds go to cancer research in the name of Stanislaw Burzynski as a birthday present to publicize his many misdeeds against cancer patients. It’s warm and cuddly. Please consider bidding to reward my MANY hours of work and support cancer research. You are welcome to call me a “knit-wit.” Click here to bid.
David Gorski already mentioned this on Monday, but Burzynski’s birthday is rapidly approaching (January 23rd) and I want to encourage our readers to donate to the Burzynski birthday campaign.
Burzynski’s misdeeds are highlighted by the stories on the website The OTHER Burzynski Patient Group If you haven’t already visited that site and read some of the stories, please do. 26 patient stories have already been posted, with another hundred or so to come. They show a pattern of lies, unethical practices, exorbitant charges, and harm to vulnerable patients. This has to be stopped!
Over $10,000 has already been raised. It’s tax deductible and easy: just click on the donate button here and supply your credit card information. The goal is to raise $30,000, the amount that a Burzynski patient typically has to pay for treatment that is misrepresented as a clinical research study! (In most legitimate clinical trials, patients are paid, not charged). The funds will be given to St. Jude Children’s Hospital for cancer research, and Burzynski will be notified on his birthday that it is a birthday present for him. He will be offered the opportunity to match whatever has been donated. He can well afford it from his ill-gotten gains. He lives in a $6 million, 14,495-square-foot mansion.
We talk a lot and complain a lot, but we seldom have an opportunity like this to actually do something, to simultaneously support science-based medicine and publicize the sins of a miscreant. Please donate.
Helke Ferrie has written an article for The CCPA Monitor, a monthly journal published by the Canadian Centre for Policy Alternatives, entitled “Dirty electricity, EMF radiation can be removed or reduced.” It is in the June 2012 issue, and is not available online. She calls herself a science writer, but this is not the writing of a person who understands science. There is hardly a word of truth in it. It’s a classic example of pseudoscientific propaganda, an appalling farrago of false statements and fallacious arguments. The nonsense starts with the very first sentence:
The symptoms of electropollution-induced sickness involve all organs with many debilitating symptoms, from skin rashes to cancer; they are part of the Multiple Chemical Sensitivity (MCS) spectrum.
The diagnoses of “electromagnetic hypersensitivity” and “multiple chemical sensitivity” are not recognized by the medical and scientific communities. Up to 5% of the population has come to attribute a large variety of nonspecific symptoms to non-ionizing electromagnetic fields from cell phones and other common electrical devices or to the chemicals in their environment. Their complaints have been thoroughly evaluated. Numerous studies and systematic reviews have been done; they are summarized in a Wikipedia article. Just to give one example, a systematic review published in Psychosomatic Medicine in 2006 analyzed 31 double blind studies comparing real radiation to sham radiation. Patients couldn’t tell the difference. 24 of the studies found no effect, 7 reported “some” supporting evidence (2 of which could not be replicated on subsequent trials by the same researchers), 3 were false positives attributed to statistical artefacts, and the final 2 had mutually incompatible results. They concluded:
The symptoms described by “electromagnetic hypersensitivity” sufferers can be severe and are sometimes disabling. However, it has proved difficult to show under blind conditions that exposure to EMF can trigger these symptoms. This suggests that “electromagnetic hypersensitivity” is unrelated to the presence of EMF.
Now that the XMRV myth has been put to rest, patients with Chronic Fatigue Syndrome (CFS) are no longer jumping the gun to demand anti-retroviral treatments. But they are jumping the gun in new ways, based on very preliminary data coming out of Norway.
A correspondent in Norway wrote to tell me patients from Norway with myalgic encephalitis/chronic fatigue syndrome (ME/CFS) are travelling to the US to have Dr. Andreas Kogelnik in San Francisco treat them with IV infusions of rituximab, apparently to no avail. A course of treatment costs over $6000, not to speak of travel and other expenses. (more…)
Vaccines, and flu shots in particular, have been covered ad nauseum on this blog; but the anti-vaccine propaganda never stops, so forgive me for bringing it up again. A correspondent inquired about a podcast by Steve Wright on Revolution Health Radio entitled “The Truth About Flu Shots (and What to do Instead).” You can either listen or read the transcript. It’s just too funny to pass up. That is, it would be funny if it weren’t endangering our public health by spreading misinformation. (more…)
We can’t stress often enough that anecdotes are not reliable evidence; but on the other hand, patient stories can serve a valuable purpose in medical education. Hearing how a disease affected an individual patient is more powerful than reading a list of symptoms in a textbook and is far more likely to fix the disease in the student’s memory. When I think of Parkinson’s disease, the first thing that comes to mind is my first patient with Parkinson’s and how he responded to levodopa; and the first thing that may come to many people’s minds is Michael J. Fox. Of course, we must realize that they may not be typical examples; but putting a face to a diagnosis serves as a memory aid and a hook to hang the rest of our knowledge on.
In his new book, The Power of Patient Stories: Learning Moments in Medicine, Paul F. Griner, MD relates more than 50 stories that distill the wisdom he has developed over a 58-year career of practicing medicine and teaching young doctors. He describes them as “stories that provided a learning moment for me.” It’s interesting to see how much medicine has changed over his professional lifetime and yet how cases from the 50s and 60s are still highly relevant. Ethical dilemmas and lessons about medical practice come alive under his pen. Each story is followed by incisive questions and exercises that engage the reader and challenge him to think about the issues. (more…)
Isagenix is a wellness system sold by multilevel marketing. It consists of a suite of products to be used in various combinations for “nutritional cleansing,” detoxification, and supplementation to aid in weight loss, improve energy and performance, and support healthy aging. It allegedly burns fat while supporting lean muscle, maintains healthy cholesterol levels, supports telomeres, improves resistance to illness, reduces cravings, improves body composition, and slows the aging process. And makes millions for distributors who got on the bandwagon early and are high on the pyramid.
I have written about it before and have been roundly criticized by its proponents. It generated my all-time favorite insult: “Dr Harriet Hall is a refrigerator with a head.”
My biggest concern with Isagenix was that it had not been clinically tested. They claimed that clinical tests were in progress (funded by Isagenix). An e-mail correspondent recently told me I should take another look at Isagenix, since a clinical study had been completed. It had not yet been published, and I asked her to get back to me when it was. Ask and you shall receive (but you may be sorry!). She contacted me when the study by Kroeger et al. was published in the journal Nutrition and Metabolism. The full study is available online and I urge readers to click on the link and look at Table 2, which I will be referring to later. The journal is peer-reviewed but, as will become painfully obvious, the peer reviewers did not do a competent job. It is an open-access online journal with a low impact factor. The authors had to pay to get their article published: it cost them $1805.