Articles

Dr. Jay Gordon and me: Random encounters with an apologist for the antivaccine movement

You are currently browsing comments. If you would like to return to the full story, you can read the full entry here: “Dr. Jay Gordon and me: Random encounters with an apologist for the antivaccine movement”.

Posted in: Neuroscience/Mental Health, Public Health, Science and the Media, Vaccines

Leave a Comment (121) ↓

121 thoughts on “Dr. Jay Gordon and me: Random encounters with an apologist for the antivaccine movement

  1. passionlessDrone says:

    Hi BisserR –

    By the way, increased MIF levels are also present in asthma, artrithis and some other autoimmune conditions, as well as in other diseases, e.g. gastric cancer:

    Thank you very much for the link. This is quite interesting. Curiously enough, we also have observed increasing rates of asthma and juvenile arthritis.

    It has also been observed in diabetes, which have also experienced globally observed increases.

    http://www.nslij.com/template.cfm?xyzpdqabc=0&id=204&action=detail&ref=706

    These guys did some interesting stuff in regards to knockout animals. It seems that inhibiting the action of MIF was sufficient to offset chemicals known to induce type 1 diabetes.

    Very interesting.

    - pD

  2. MARIALU says:

    Hi pD
    The innate immune asnwer is being more and more studied. There is very recent literature on the topic that is very interesting and in line with the MIF and the topic in study.

    Alum has been shown to activate the inflammasome through caspase-1 activation, IL-1Beta and Il-18 and this is the basis of the immunostimulatory effect in vaccines. Alum has been used without the knowledge of the mechanism of the stimulation of the immune system… for a century

    Nature. 2008 Jun 19;453(7198):1122-6. Epub 2008 May 21.
    Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.Eisenbarth SC, Colegio OR, O’Connor W, Sutterwala FS, Flavell RA.
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
    Aluminium adjuvants, typically referred to as ‘alum’, are the most commonly used adjuvants in human and animal vaccines worldwide, yet the mechanism underlying the stimulation of the immune system by alum remains unknown. Toll-like receptors are critical in sensing infections and are therefore common targets of various adjuvants used in immunological studies. Although alum is known to induce the production of proinflammatory cytokines in vitro, it has been repeatedly demonstrated that alum does not require intact Toll-like receptor signalling to activate the immune system. Here we show that aluminium adjuvants activate an intracellular innate immune response system called the Nalp3 (also known as cryopyrin, CIAS1 or NLRP3) inflammasome. Production of the pro-inflammatory cytokines interleukin-1beta and interleukin-18 by macrophages in response to alum in vitro required intact inflammasome signalling. Furthermore, in vivo, mice deficient in Nalp3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) or caspase-1 failed to mount a significant antibody response to an antigen administered with aluminium adjuvants, whereas the response to complete Freund’s adjuvant remained intact. We identify the Nalp3 inflammasome as a crucial element in the adjuvant effect of aluminium adjuvants; in addition, we show that the innate inflammasome pathway can direct a humoral adaptive immune response. This is likely to affect how we design effective, but safe, adjuvants in the future.

    http://www.freerepublic.com/focus/f-news/2019565/posts

    “The Nalp3 inflammasome is known to be activated by compounds of microbial origin and also by molecules that appear when cells die, such as uric acid. So researchers think that Nalp3 is like a “danger sensor,” says Yale immunologist Stephanie Eisenbarth, the first author on the Nature paper. Alum-containing vaccines may simply “hijack” that response
    Knowing how alum works its magic may help researchers design more specific adjuvants that are more effective or have fewer side effects, HogenEsch says. Alum, for instance, is known to kill muscle cells when injected into muscles, as many vaccines are”

    J Child Neurol. 2008 Jun;23(6):614-9. Epub 2008 Feb 15.
    Macrophagic myofasciitis in children is a localized reaction to vaccination.Lach B, Cupler EJ.
    Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
    Macrophagic myofasciitis is a novel, “inflammatory myopathy” described after a variety of vaccinations, almost exclusively in adults. We examined the relevance of histological findings of this myopathy to the clinical presentation in pediatric patients. Muscle biopsies from 8 children (7 months to 6 years old) with histological features of macrophagic myofasciitis were reviewed and correlated with the clinical manifestations. Patients underwent quadriceps muscle biopsy for suspected mitochondrial disease (4 patients), spinal muscular atrophy (2 patients), myoglobinuria (1 patient), and hypotonia with motor delay (1 patient). All biopsies showed identical granulomas composed of periodic acid-Schiff-positive and CD68-positive macrophages. Characteristic aluminum hydroxide crystals were identified by electron microscopy in 2 cases. The biopsy established diagnoses other than macrophagic myofasciitis in 5 patients: spinal muscular atrophy (2), Duchenne muscular dystrophy (1), phospho-glycerate kinase deficiency (1), and cytochrome c oxidase deficiency (1). Three children with manifestations and/or a family history of mitochondrial disease had otherwise morphologically normal muscle. All children had routine vaccinations between 2 months and 1 year before the biopsy, with up to 11 intramuscular injections, including the biopsy sites. There was no correlation between histological findings of macrophagic myofasciitis in biopsies and the clinical symptoms. We believe that macrophagic myofasciitis represents a localized histological hallmark of previous immunization with the aluminum hydroxide adjuvants contained in vaccines, rather than a primary or distinct inflammatory muscle disease.

    AND…

    Arthritis Rheum. 2008 Mar;58(3):888-94.
    Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?Verma D, Lerm M, Blomgran Julinder R, Eriksson P, Söderkvist P, Särndahl E.
    Linköping University, Linköping, Sweden.

    OBJECTIVE: NALP3, ASC, and TUCAN are components of the NALP3 inflammasome, which triggers caspase 1-mediated interleukin-1beta (IL-1beta) release. Activating mutations in the gene encoding NALP3 (NLRP3) have recently been linked to familial periodic fever syndromes. We undertook this study to determine whether a patient with arthritis and antibiotic-resistant fever carried mutations in the genes encoding the NALP3 inflammasome. METHODS: Genetic analysis of NLRP3 and the gene encoding TUCAN (CARD-8) was performed on genomic DNA from the patient and from a population-based collection of DNA (806 subjects). For in vitro studies of IL-1beta production and caspase 1 activity, blood was obtained from the patient at different time points after administration of anakinra, an IL-1 receptor antagonist, as well as from 5 healthy age- and sex-matched control subjects. RESULTS: Mutation analysis of the patient’s genes encoding NALP3, ASC, and TUCAN revealed variations in the NLRP3 (Q705K) and CARD-8 (C10X) genes. The allele frequencies of these single-nucleotide polymorphisms (SNPs) in the population were 6.5% and 34%, respectively. The elevated activity of caspase 1 and the high levels of IL-1beta measured in samples from the patient returned to normal levels after treatment with anakinra. CONCLUSION: Our results indicate that the patient’s symptoms were due to elevated levels of IL-1beta, since treatment with anakinra effectively abolished the symptoms. The compound SNPs may explain the increased IL-1beta levels and inflammatory symptoms observed, but further studies are needed to reveal a functional relationship. The prevalence of the polymorphisms (4% of the population carry both SNPs) in the general population may suggest a genetic predisposition for common inflammatory disorders.

    6.5 %, 34 % and 4 % of the population….

    With the reported alterations in gut microbiota in ASD this is particularly interesting also….
    PLoS ONE. 2008 Aug 26;3(8):e3064.
    Predominant role of host genetics in controlling the composition of gut microbiota.
    Khachatryan ZA, Ktsoyan ZA, Manukyan GP, Kelly D, Ghazaryan KA, Aminov RI.
    Laboratory of Molecular Genetics, Institute of Molecular Biology of Armenian National Academy of Sciences, Yerevan, Armenia.
    BACKGROUND: The human gastrointestinal tract is inhabited by a very diverse symbiotic microbiota, the composition of which depends on host genetics and the environment. Several studies suggested that the host genetics may influence the composition of gut microbiota but no genes involved in host control were proposed. We investigated the effects of the wild type and mutated alleles of the gene, which encodes the protein called pyrin, one of the regulators of innate immunity, on the composition of gut commensal bacteria. Mutations in MEFV lead to the autoinflammatory disorder, familial Mediterranean fever (FMF, MIM249100), which is characterized by recurrent self-resolving attacks of fever and polyserositis, with no clinical signs of disease in remission. METHODOLOGY/PRINCIPAL FINDINGS: A total of 19 FMF patients and eight healthy individuals were genotyped for mutations in the MEFV gene and gut bacterial diversity was assessed by sequencing 16S rRNA gene libraries and FISH analysis. These analyses demonstrated significant changes in bacterial community structure in FMF characterized by depletion of total numbers of bacteria, loss of diversity, and major shifts in bacterial populations within the Bacteroidetes, Firmicutes and Proteobacteria phyla in attack. In remission with no clinical signs of disease, bacterial diversity values were comparable with control but still, the bacterial composition was substantially deviant from the norm. Discriminant function analyses of gut bacterial diversity revealed highly specific, well-separated and distinct grouping, which depended on the allele carrier status of the host. CONCLUSIONS/SIGNIFICANCE: This is the first report that clearly establishes the link between the host genotype and the corresponding shifts in the gut microbiota (the latter confirmed by two independent techniques). It suggests that the host genetics is a key factor in host-microbe interaction determining a specific profile of commensal microbiota in the human gut.

    Now I wonder
    a-How many autistics carry the NLRP3 AND /OR CARD8 AND/OR MIF polymorphisms? How many one or the other? What is the impact in mitochondrial function and the BBB and the gut permeability when Alum is present in the vaccines that are given at a pediatric visit- 5-7-9 vaccines in 2/3 injections?
    b-What impact has the IL-1Beta/IL-18 and caspase 1 activation , especially with the other cytokines activations that are needed and known that take place during the full vaccination schedule (IL-6 in the flu; Il-2 in the HepB vaccine, to begin with) with the known differences in NK that autistic children have- to begin with-and has been published from the genetics and the physiologic point of view?
    c-What is the role of the bystander activation and molecular mimicry of toxoid bacterial or viral compounds in vaccines in accumulation considering the innate immune activation and for example the Vargas et al study- in the fertile field hypothesis context of the analysis of autoimmunity-in particular for example type 1 diabetes and autoinflammatory syndromes?

    All of these are unexplored lines of research in ASD.

  3. passionlessDrone says:

    Hello friends –

    In case anyone is stil paying attention, which I doubt, we do seem to have some preliminary laboratory evidence that some children with autism will display differential responses in terms of cytokine production when their toll like receptors are stimulated with agonists.

    http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/708.17

    Increased MIF may be a component of this, though there are likely other factors.

    OK!

    - pD

  4. jody says:

    I sent this to a Dr. Novella who was attacking David Kirby author of Evidence of harm
    You who keep thinking that the science is in, your right. And it’s not good for the CDC’s EX DIR. This is the latest about the CDC ‘s science “As questionable as the US thimerosal study was, “it was an improvement on other studies, including the two in Denmark, both of which had serious weaknesses in their designs,” Dr. Irva Hertz-Picciotto, Professor of Public Health at UC Davis Medical School and Chair of the NIEHS panel, told reporter Dan Olmsted at UPI.That leaves very little for the CDC to go on in terms of proving that thimerosal and autism are not associated in any way”. “CDC Director Dr. Julie Gerberding has delivered a potentially explosive report to the powerful House Appropriations Committee, in which she admits to a startling string of errors in the design and methods used in the CDC’s landmark 2003 study that found no link between mercury in vaccines and autism, ADHD, speech delay or tics.Gerberding was responding to a highly critical 2006 report from the National Institute of Environmental Health Sciences (NIEHS), which concluded that the CDC’s flagship thimerosal safety study was riddled with “several areas of weaknesses” that combined to “reduce the usefulness” of the study”. This is the Dir. of the CDC ‘s response to the allegations that their flag ship studies were fatally flawed according to congress and the NEIHS “CDC concurs,” Dr. Gerberding wrote in an undated mea culpa to Congress, (provided to me through a Capital Hill staffer) That leaves them with nothing left! ( Nothing ) This is the CDC Dir. admitting that they have no science left to refute the autism thimerosal connection, but give them some more time, and they will produce good quality studies. I believe when they were first warned the autism rate was 1 in 10,000 they chose to ignore the warning, and every piece of research that they did in their words, was well designed robust studies. We are learning that they were useless. So I guess we can say at the least, The Dir. of the CDC was incompatant, and at the worse the Dir. was involved in a criminal cover up. But I do believe we have given them long enough time to investigate themselves. after all would you let ENRON investigate ENRON also I’m afraid if we give them anymore time we won’t have any children left. from 1 in 10,000 to 1 in 82 and that’s not even taken into account a 4 to 1 ratio boy’s to girls we in the U.S. should have the same penalties that China has, they put people to death when they are this incompatant. I think if there were consequences example from China for this kind of incompetence I believe our children would not be for sell to the highest bidder from big Pharma. as high profit guinea pigs Dad of Colton a severely vaccine damaged child that was mercury poisoned by the standard of care set by the Centers for Disease Control and Prevention’s Advisory Committee on Immunizations

  5. David Gorski says:

    Please see my comment in response to the copy of this comment that you posted in response to one of Steve’s posts:

    http://www.sciencebasedmedicine.org/?p=340#comment-12379

  6. Prometheus says:

    Since “jody” posted the same breathless comment on my ‘blog, I’ll answer her here and limit the spread of her fact-free conspiracy theorem.


    “As questionable as the US thimerosal study was, “it was an improvement on other studies, including the two in Denmark, both of which had serious weaknesses in their designs,” Dr. Irva Hertz-Picciotto, Professor of Public Health at UC Davis Medical School and Chair of the NIEHS panel, told reporter Dan Olmsted at UPI.

    From context, I assume that the “CDC’s landmark 2003 study” Jody refers to is the Verstraeten et al study. There were, of course, limitations in this study, as there are in all research. Howver, its findings have been confirmed by several subsequent studies, including the “study” started in 2001 when thimerosal was removed from childhood vaccines.

    Curiously, the “autism epidemic” continues apace despite thimerosal having been removed (or reduced to “trace” levels, if you like) over seven years ago. I’d say that the connection between thimerosal and autism is pretty much a dead issue except for those whose livlihood depends on it.

    The Thompson et al (2007) study confirmed that thimerosal was not associated with neurological impairment except that they noted a small increase in motor tics (also seen in Verstraeten et al) and a small increase in performance IQ in boys associated with higher thimerosal exposure.

    There is a study looking specifically at thimerosal exposure and autism that should be reported soon. I expect that it will confirm what common sense has been telling us (given the continued rise in autism prevalence despite the profound drop in thimerosal exposure).

    “Jody” clearly has a deep committment to the “thimerosal-causes-autism” hypothesis and appears distraught that it is dying (actually, it is already dead, but close friends are keeping it on life support). Part of science is the acceptance that we cannot keep our hypotheses alive without supporting data. In fact, it is folly to try to do so.

    Prometheus

  7. sammy1 says:

    I will try to keep this short… RationalJen I would say that your coment(f!@# you) is juvenial at best. High intellegence there.
    Also, to say that vaccines are completly safe is intellectual suicide. the National Vaccine Injury Compensation program has paid out OVER 1.2 BILLION dollars since 1986 to families of vaccine injuries or vaccine related death. Now, I am not advocating either side. I am simply saying that more research obviously is needed. Autism is not a new word. Some of the earliest published descriptions of Autism date as far back as the 18th century. However, “Autism” did not receive its name until the 20th century. I think its worthy to note that in the early days of vaccines, only the wealthy had oppertunity to become vaccinated. Research has shown that since vaccines were made available to all walks of life, Autism has increased. Again, I am not advocating. I am presenting info that no one has mentioned.
    I do believe in vaccinating children. I also believe those vaccines have a risk. As far as statistics and studys I can tell that nothing is 100%. Where man is in charge there you will find mistakes. I will also mention that I was the 0.001% of women to get pregnant on the depo-provera shot. I know its not related to Autism, but thats pretty good for haveing less than 1% chance. There are children with disabilities due to vaccines because they were also the less than 1% statistic. And yes, my family is dealing with Autism personally.

  8. Dr Benway says:

    Research has shown that since vaccines were made available to all walks of life, Autism has increased.

    Research has shown that with the increase in global warming, autism has increased.

    Too easy, I’m afraid.

Comments are closed.