Search Results for "ioannidis"

  1. Buteyko Breathing Technique – Nothing to Hyperventilate About
    A reader recently sent in a link to a New York Times article that discussed an alternative breathing technique developed in Russia for the treatment of asthma called the Buteyko Method, or the Buteyko Breathing Technique (BBT), and asked for an evaluation of the claims on SBM.  This post will attem…
  2. Lithium for ALS – Angioplasty for MS
    Peter Lipson reported Monday about new research suggesting that Multiple Sclerosis may be caused by venous blockage. He correctly characterized some of the hype surrounding this story as “irrational exuberance.” This is a phenomenon all too common in the media – taking the prelimin…
  3. Bibliography for my Talk at TAM 7: Why Evidence-Based Medicine is not yet Science-Based Medicine
    As promised at the meeting. Let me know by comment if you think I left anything out. (more…) …
  4. Does popularity lead to unreliability in scientific research?
    One of the major themes here on the Science-Based Medicine (SBM) blog has been about one major shortcoming of the more commonly used evidence-based medicine paradigm (EBM) that has been in ascendance as the preferred method of evaluating clinical evidence. Specifically, as Kim Atwood (1, 2, 3, 4, 5,…
  5. Cancer research: Going for the bunt versus swinging for the fences
    A couple of weeks ago, our resident skeptical medical student Tim Kreider wrote an excellent article about an op-ed in NEWSWEEK by science correspondent Sharon Begley, in which he pointed out many misconceptions she had regarding basic science versus translational research, journal impact factors, a…
  6. Human subjects protections and research ethics: Where the rubber hits the road for science-based medicine
    Arguably the most difficult aspect of science-based medicine is where the rubber hits the road, so to speak. That’s where scientists and physicians take the results of preclinical studies performed in vitro in biochemical assays and cell culture models and in vivo in animal models to humans. T…
  7. Bad Books
    In the interests of fairness and intellectual honesty, I’ve forced myself to read a lot of really bad books. The True Believer tells me his guru’s book is the Real Stuff. He tells me I have a closed mind and won’t look at anything outside establishment dogma, and if I only read the book and un…
  8. Fakin’ it
    Last week the Times of London revealed inside information from the General Medical Council (UK, responsible for physician licensing) of an ongoing investigation of Dr. Andrew Wakefield and from its own investigation. This revelation recalled other instances of fakery from reports of sectarian medici…
  9. On the dangers of using valid placebo controls in clinical trials of acupuncture
    I don’t recall if I’ve ever mentioned this before on this blog, but there was a time when I was less skeptical of acupuncture than I am now. It’s true. Don’t get me wrong, though. I never for a minute considered that the whole rigamarole about “unblocking” or R…
  10. Interpreting the Medical Literature
    The science in science-based medicine includes all of science, but relies most heavily on the biomedical literature – published studies that collectively represent our scientific medical knowledge. The scientific basis of medicine is only as good as this body of knowledge and the manner in whi…
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