Results for: ioannidis
Debunking the magical power of the placebo effect for chronic pain (yet again)
The opioid crisis and growing awareness of the dangers of addiction to pain medication are prompting renewed calls for the use of pill placebos in place of active treatments, backed by familiar claims about the magical powers of the placebo.
Estrogen Matters
Hormone replacement therapy in menopause is safer and more effective than we have been led to believe. A new book examines the evidence and sets the record straight.
The Debate Is Over: Antidepressants DO Work Better Than Placebo
The idea that antidepressants are no more effective than placebo has been put to rest. They clearly work when used appropriately, although the effect size is not as large as the published studies have suggested.
Rigor Mortis: What’s Wrong with Medical Science and How to Fix It
Medical research has been plagued by less-than-rigorous practices and a culture that rewards quantity over quality. In a new book, Richard Harris identifies the problems, proposes solutions, and offers hope.
0.05 or 0.005? P-value Wars Continue
The p-value is under fire yet again, but this time with some quick-and-dirty solutions (and some long-and-onerous ones too) to the problems created by relying on this quick-and-dirty test.
Can mind-body practices “reprogram” our DNA?
A recent systematic review has been touted as demonstrating that "mind-body" practices like yoga can reprogram our DNA. There are several reasons to doubt these claims, not the least of which is the history of bias in past studies on this topic.
Responding to SBM Critics
A response to a critic of SBM, and setting the record straight on our actual positions regarding evidence and the practice of medicine.
Medical science policy in the U.S. under Donald Trump eighty days in
A week after Donald Trump was elected, I speculated about how he would affect medical science policy. Now, 80 days into the Trump administration, we have some observations.
Peanut Allergy Prevention Advice Does a 180
New guidelines suggest that preventing peanut allergies may be as simple as giving peanut-containing food, beginning in infancy. How did old guidelines, which recommended avoidance, get it so wrong?
A right to science
Unless forced to do so, the state and federal governments will continue to base law and policy on bad science. Maybe it's time for a constitutional amendment guaranteeing a "right to science."