Month: September 2010
Evidence-Based Medicine, Human Studies Ethics, and the ‘Gonzalez Regimen’: a Disappointing Editorial in the Journal of Clinical Oncology Part 2
NB: If you haven’t yet read Part 1 of this blog, please do so now; Part 2 will not summarize it. … At the end of Part 1, I wrote: We do not need formal statistics or a new, randomized trial with a larger sample size to justify dismissing the Gonzalez regimen. In his editorial for the JCO, Mark Levine made a...
Using attacks on science by the anti-vaccine movement as a “teachable moment”
A new study on the connection between vaccines and autism demonstrates two things: there is no connection, and those who think there is are not interested in science unless it supports what they already believe.
Evidence-Based Medicine, Human Studies Ethics, and the ‘Gonzalez Regimen’: a Disappointing Editorial in the Journal of Clinical Oncology Part 1
Background: the distinction between EBM and SBM An important theme on the Science-Based Medicine blog, and the very reason for its name, has been its emphasis on examining all the evidence—not merely the results of clinical trials—for various claims, particularly for those that are implausible. We’ve discussed the distinction between Science-Based Medicine (SBM) and the more limited Evidence-Based Medicine (EBM) several times,...
Aspartame – Truth vs Fiction
If you believe everything you read on the internet, then it seems that a chemical found in thousands of products is causing an epidemic of severe neurological and systemic diseases, like multiple sclerosis and lupus. The FDA, the companies that make the product, and the “medical industrial complex” all know about the dangers of this chemical but are hiding the truth from...
Brain Balance
A member of Quackwatch’s Healthfraud discussion list recently reported from a health fair: One booth was a bit of a mystery for me: Brain Balance. “Is your child struggling with ADHD, dyslexia, autism, Asperger’s, Tourette’s, or other related disorders?” A quick glance at their website makes it seem that they may be legitimate. No, a quick glance at their website makes it...
The final nail in the mercury-autism hypothesis?
Another study. Another failure to link thimerosal to a higher risk of autism. Can we just bury the claim that thimerosal in vaccines causes autism, already?
Chronic Fatigue Syndrome: Lots of Speculation
Humans love to find patterns in the world. Sometimes patterns exist, sometimes they are imaginary. Sometimes you can see a pattern that may be interesting and ignore its significance. As a resident I used to say that anyone who smokes three packs of cigarettes a day has to be schizophrenic, it was meant more as a joke, when, in fact, it was...
Your disease, your fault
Earlier this week, my colleague Dr. Gorski explored a common theme in alternative medicine: the idea that all disease is preventable. This implies that all disease has a discrete cause and that individual behavior can mitigate this cause. If biology worked this way, my job as an internist would be very different. Many people would love to believe that life is this...
Ghostwriting As Marketing Tool
An article in the latest issue of PLOS Medicine, The Haunting of Medical Journals: How Ghostwriting Sold “HRT”, details the use of ghostwriting as a marketing tool for pharmaceutical companies. It is a chilling discussion of how at least one pharmaceutical company, Wyeth, used the peer-reviewed literature as a method of distributing marketing messages to physicians. The author, Adriane J. Fugh-Berman, details...
Write for Oprah? Wrong for Me
From January through June of 2010 I wrote a column entitled “The Health Inspector” in O, The Oprah Magazine. Now, apparently, I have been fired; although they have not had the common courtesy to tell me so. The whole thing has been a bizarre, frustrating experience. It started last fall, when I got an e-mail from Tyler Graham. He introduced himself as...