Search Results for "ioannidis"

  1. The Science of Clinical Trials
    Science-based medicine is partly an exercise in detailed navel gazing – we are examining the use of science in the practice of medicine. As we use scientific evidence to determine which treatments work, we also have to examine the relationship between science and practice, and the strengths an…
  2. “Postnatal depression blood test breakthrough” or Churnalism?
    “Postnatal depression blood test breakthrough” proclaimed the headline. The UK Guardian article then declared: British doctors reveal ‘extremely important’ research that could help tens of thousands of women at risk. Here it comes. Readers were going to be fed a press release generat…
  3. Homeopathy Ramblings
    There needs to be a SCAM index, some quantitative tool, a formula for ranking the SCAMs, so one SCAM could reign supreme, to be definitely declared the the goofiest of all SCAMs. Perhaps (number of adherents)x(number of Pubmed publications)x(age of SCAM) all divided by a plausibility factor. Homeopa…
  4. Coenzyme Q10 for heart failure: The hype and the science
    Could a product sold as a dietary supplement really be delivering the benefits that advocates have claimed for decades? That’s what you might be wondering about coenzyme Q10, following recent stories like: The energy-boosting supplement that could HALVE the number of deaths from heart failure…
  5. Acupuncture Doesn’t Work
    About a year ago the editors of Anesthesia & Analgesia solicited a written debate on whether or not acupuncture is effective or simply an elaborate placebo. Four experienced acupuncture researchers agreed to write the pro-acupuncture article, Wang, Harris, Lin and Gan. They asked David Colquhoun…
  6. AAFP CME Program Succumbs to “Integrative Medicine”
    For many years I have been using Continuing Medical Education (CME) programs offered by the American Academy of Family Physicians (AAFP). The FP Essentials program consists of a monthly monograph with a post-test that can be submitted electronically for 5 hours of CME credit. Over a 9-year cycle, a …
  7. Everything we eat causes cancer…sort of
    Read meat causes cancer. No, processed meat causes cancer. OK, it’s both read meat and processed meat. Wait, genetically modified grain causes cancer (well, not really). No, aspartame causes cancer. No, this food coloring or that one causes cancer. Clearly, everything you eat causes cancer! Th…
  8. The NIH funding process: “Conformity” and “mediocrity”?
    When we refer to “science-based medicine” (SBM), it is a very conscious choice to emphasize that good medicine should be based on a solid foundation of science. The name was coined to contrast the difference between the current evidence-based medicine (EBM) paradigm, which fetishizes ran…
  9. I Never Meta Analysis I Really Like
    David Gorski recently pointed out that Science Based Medicine is going on five years. Amazing. That there would be so much to write about day after day comes as a surprise to me. Somehow I vaguely thought that ‘controversies’ would be resolved. Pick a SCAM, contrast the SCAM with reality…
  10. Low Level Lasers: N-Rays in action.
    I do not want to get all angsty and omphaloskeptic, but I have been thinking more of late about the purpose of the blog and my role in it.  Blogs,and the people who write them,  are ephemeral.  It takes a unique personality and commitment to churn out these essays and commit them to the ether.  …
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