Results for: placebo
The Debate Is Over: Antidepressants DO Work Better Than Placebo
The idea that antidepressants are no more effective than placebo has been put to rest. They clearly work when used appropriately, although the effect size is not as large as the published studies have suggested.
Placebo Myths Debunked
Placebo treatments are often sold as magical mind-over-matter healing effects, but they are mostly just illusions and non-specific effects.
Is the use of “Open-Label” Placebo Ethical in the Treatment of Children?
Is the use of "open-label" placebo ethical in pediatric medical care, or any care for that matter? A recent article in Pediatrics discussing this issue comes to a flawed conclusion based on a misunderstanding of placebo and of the literature on placebo without deception.
Can the mind really heal the body? The false narrative of placebo “healing” revisited
Placebo effects are inextricably bound to the question of whether the alternative medicine modalities that are being “integrated” into medicine actually have any useful therapeutic effects or not; i.e., whether they are merely placebos. Here, I examine an article in National Geographic that peddles the false narrative that placebo effects have real "healing" powers against diseases like Parkinson's disease.
A Credible Placebo Control for Chiropractic Research
The research on chiropractic has been far from rigorous. One of the problems is that studies of spinal manipulation therapy (SMT) can’t be double blinded, and it is very difficult to even do single blinding. So most studies resort to non-manipulation control groups like “usual care” or “wait list” or “pain medication.” Those studies are practically guaranteed to lead to false positive...
Cure Is About Caring, Not Curing: Placebos, Alternative Medicine, and Patient Comfort
In a recent post, Dr. Gorski criticized two articles by Jo Marchant on placebos and alternative medicine. He mentioned that she had a book coming out and suggested I might want to review it. The title is Cure: A Journey into the Science of Mind Over Body. I don’t know of any evidence that the mind has ever cured a disease, so...
Is “harnessing the power of placebo” worthwhile to treat anything?
We frequently write about placebo effects here on Science-Based Medicine. The reason is simple. They are an important topic in medicine and, at least as importantly, understanding placebo effects is critical to understanding the exaggerated claims of advocates of “complementary and alternative medicine” (CAM), now more frequently called “integrative medicine” (i.e., integrating pseudoscience with science). Over the years, I (and, of course,...
Are Placebos Getting Stronger?
A new study looked at clinical trials for neuropathic pain over the last 23 years and found that the response of subjects in the placebo group has been increasing over time, but only in the United States. The cause of this increase is unknown, and has provoked a fascinating discussion about the nature of placebos and their role in medical research. What...
Placebo by Conditioning
Truly understanding placebo effects (note the plural) is critical to science-based medicine. Misconceptions about placebo effects are perhaps the common problem I encounter among otherwise-scientific professionals and science communicators. The persistence of these misconceptions is due partly to the fact that false beliefs about placebos, namely that “the” placebo effect is mainly an expectation mind-over-matter effect, is deeply embedded in the culture....
Should placebos be used in randomized controlled trials of surgical interventions?
Trials of new experimental drugs frequently compare them to placebo, particularly when there is a large subjective component to the disease being treated, such as pain. In contrast, placebo-controlled trials are rarely undertaken in surgery, mainly because it's been considered ethically dicey to do sham surgery on one group. Should this change? Should we be more open to doing randomized, placebo-controlled surgery...