Results for: ioannidis

Evidence-Based Medicine, Human Studies Ethics, and the ‘Gonzalez Regimen’: a Disappointing Editorial in the Journal of Clinical Oncology Part 1

Background: the distinction between EBM and SBM An important theme on the Science-Based Medicine blog, and the very reason for its name, has been its emphasis on examining all the evidence—not merely the results of clinical trials—for various claims, particularly for those that are implausible. We’ve discussed the distinction between Science-Based Medicine (SBM) and the more limited Evidence-Based Medicine (EBM) several times,...

/ September 17, 2010

The Living Matrix: A Movie Promoting Energy Medicine Beliefs

It’s boring to try to ferret out reliable health information from dry medical journals. It’s easier and more fun to watch a movie. A new movie promises to change the way you think about your health. To bring you breakthroughs that will transform your understanding of how to get well and stay well. To share the discoveries of leading researchers and health...

/ June 15, 2010

Low Dose Naltrexone – Bogus or Cutting Edge Science?

On SBM we have documented the many and various ways that science is abused in the pursuit of health (or making money from those who are pursuing health). One such method is to take a new, but reasonable, scientific hypothesis and run with it, long past the current state of the evidence. We see this with the many bogus stem cell therapy...

/ May 5, 2010

The life cycle of translational research

I’m a translational researcher. To those of you who aren’t familiar with what that means, it means (I hope) that I study potential therapies in the lab and try to translate them into actual therapies that will cure patients of breast cancer — or, at the very least, improve their odds of survival or prolong survival when cure is not possible. Translational...

/ January 4, 2010

Buteyko Breathing Technique – Nothing to Hyperventilate About

A reader recently sent in a link to a New York Times article that discussed an alternative breathing technique developed in Russia for the treatment of asthma called the Buteyko Method, or the Buteyko Breathing Technique (BBT), and asked for an evaluation of the claims on SBM.  This post will attempt to be a reasonably comprehensive evaluation of Buteyko and his therapy...

/ December 25, 2009

Lithium for ALS – Angioplasty for MS

Peter Lipson reported Monday about new research suggesting that multiple sclerosis may be caused by venous blockage. He correctly characterized some of the hype surrounding this story as “irrational exuberance.” This is a phenomenon all too common in the media – taking the preliminary research of an individual or group (always presented as a maverick) and declaring it a “stunning breakthrough,” combined...

/ December 23, 2009

Bibliography for my Talk at TAM 7: Why Evidence-Based Medicine is not yet Science-Based Medicine

As promised at the meeting. Let me know by comment if you think I left anything out.

/ July 11, 2009

Does popularity lead to unreliability in scientific research?

One of the major themes here on the Science-Based Medicine (SBM) blog has been about one major shortcoming of the more commonly used evidence-based medicine paradigm (EBM) that has been in ascendance as the preferred method of evaluating clinical evidence. Specifically, as Kim Atwood (1, 2, 3, 4, 5, 6, 7, 8) has pointed out before, EBM values clinical studies above all...

/ July 6, 2009

Cancer research: Going for the bunt versus swinging for the fences

A couple of weeks ago, our resident skeptical medical student Tim Kreider wrote an excellent article about an op-ed in NEWSWEEK by science correspondent Sharon Begley, in which he pointed out many misconceptions she had regarding basic science versus translational research, journal impact factors, and how journals actually determine what they will publish. Basically, her thesis rested on little more than a...

/ June 29, 2009
Translational research and preclinical data

Human subjects protections and research ethics: Where the rubber hits the road for science-based medicine

Although clinical trials are science, they often can't be controlled as well as experiments in most branches of science. The reason is that the experimental subjects are human, and ethics demands that risks and harms be minimized and benefits maximized.

/ April 27, 2009