Tag: randomized clinical trial

RFK Jr. no saline placebo

RFK Jr. resurrects an old antivax half-truth about “saline placebos” in randomized controlled trials of vaccines

Robert F. Kennedy, Jr. has resurrected the antivax claim that the childhood vaccine schedule has never been tested in randomized controlled trials (RCTs) with a saline placebo controls (and therefore the vaccine schedule is unsafe). This is an old and deceptive antivax half-truth that ignores both what constitutes a scientifically valid placebo and the ethical requirements for RCTs.

/ July 3, 2023
Cochrane Collaborative

The Cochrane mask fiasco: How the evidence-based medicine paradigm can produce misleading results

Last week, the Cochrane Collaborative was forced to walk back the conclusions of a review by Tom Jefferson et al that had been spun in the media as proving that "masks don't work." Tom Jefferson himself has been problematic about vaccines for a long time, but the rot goes deeper. What is it about the evidence-based medicine paradigm that results in misleading...

/ March 13, 2023
Ivermectin repurposing

Science-based medicine isn’t just for CAM. The case of ivermectin shows that it never was.

Another large randomized controlled trial for ivermectin showed no efficacy for the early treatment of COVID-19. This is not a surprise to science-based medicine advocates. Here's why the story of ivermectin shows that SBM isn't just for "complementary and alternative medicine" (CAM) —and never was.

/ April 4, 2022
Ivermectin repurposing

Ivermectin: The acupuncture of COVID-19 treatments

As high-quality evidence increasingly and resoundingly shows that ivermectin does not work against COVID-19, advocates are doing what acupuncture advocates do: Turning to lower quality "positive" studies to claim incorrectly that their favorite ineffective treatment actually does "work".

/ March 21, 2022

A New Study Finds No Benefit from Chiropractic for Infant Colic, but They’ll Keep Doing it Anyway

A new study attempted to answer the question of chiropractic's potential benefit for infant colic. It was successful, but I don't think it turned out the way the authors' hoped. Sadly, I don't think that this will change the mind of any chiropractor who treats babies.

/ July 23, 2021
Pfizer/BioNTech COVID-19 vaccine

To unblind or not to unblind? That is the question about clinical trials of COVID-19 vaccines

Antivaccine alternative health tycoon Joe Mercola claims that the unblinding of participants in the clinical trials of Moderna and Pfizer COVID-19 vaccines was intended to "blow up the trials" and undermine the science, making it impossible ever to identify long term adverse events. What he's really doing is deceptively oversimplifying complex ethical and scientific issues surrounding these trials in the middle of...

/ April 26, 2021

Vitamin D shows no efficacy against moderate to severe COVID-19 infections

A new trial failed to find evidence that a massive dose of vitamin D improves outcomes in patients with moderate to severe COVID-19 infections.

/ March 4, 2021

Overtreating the thyroid

For decades there's been debate about whether thyroid medication is necessary for a mild form of thyroid dysfunction. A new trial helps answer that question.

/ April 20, 2017