Category: Clinical Trials
ORBITA: Another clinical trial demonstrating the need for sham controls in surgical trials
Last week, the results of ORBITA were published. This clinical trial tested coronary angioplasty and stenting versus optimal medical management in patients with single-vessel coronary artery disease. It was a resoundingly negative trial, meaning that adding stenting to drug management didn't result in detectable clinical improvement. What was distinctive about this trial is that it used a sham procedure (i.e., placebo) control,...
Rigvir strikes back, or: A conversation with a Rigvir flack
My skeptical analysis of Rigvir, a "Virotherapy" from Latvia being promoted by alternative medicine clinics as a cancer cure, caught the attention of the International Virotherapy Center (IVC). The result was a long and very telling e-mail exchange between its Assistant of Business Development and myself. I post it because the arguments used in the discussion are very telling about where the...
Ty Bollinger’s “The Truth About Cancer” and the unethical marketing of the unproven cancer virotherapy Rigvir
Last week, I wrote about Rigvir, a "virotherapy" promoted by the International Virotherapy Center (IVC) in Latvia, which did not like what I had to say. When a representative called me to task for referring to the marketing of Rigvir using patient testimonials as irresponsbile, it prompted me to look at how Ty Bollinger's The Truth About Cancer series promoted Rigvir through...
Rigvir: Another unproven and dubious cancer therapy to be avoided
Recently, the Hope4Cancer Institute, a quack clinic in Mexico, has added a treatment known as Rigvir to its coffee enemas and other offerings. But what is Rigvir? It turns out that it's an import from Latvia with a mysterious history. Proponents claim that it is an oncolytic virus that targets cancer specifically and leaves normal cells alone. Unfortunately, there is a profound...
“New vaccine replaces statins?” Not So Fast!
News reports suggest new drugs may replace statins. PSCK9 inhibitors are useful, but only along with statins in high risk patients not controlled on statins alone, or for patients who can't tolerate statins. They're not about to replace statins.
Alternative medicine kills cancer patients
By definition, alternative medicine has not been shown to be effective or has been shown to be ineffective. Thus, alternative medicine is ineffective against cancer and can best be represented as either no treatment at all or potentially harmful treatment. It is thus not surprising that cancer patients who choose alternative medicine have a higher risk of dying from their cancer. A...
AllerVarx: A Questionable Remedy for Allergic Rhinitis
AllerVarx, a new dietary supplement, claims to relieve nasal allergy symptoms, but the only "evidence" is a single disreputable clinical trial with no control group. There is no reason to try this unproven remedy when there are so many effective remedies offered by mainstream medicine.
Does chemotherapy cause cancer to spread?
Earlier this month, a study was published in Science Translational Medicine that showed how chemotherapy before surgery can stimulate breast cancer invasiveness and invasion under certain circumstances. Not surprisingly, alternative cancer cure mavens everywhere are spinning the study as "proof" that chemotherapy has no benefit and causes only harm (and so you should buy their nostrums instead). Unsurprisingly, the actual results are...
Emergency acupuncture!
For whatever reason, acupuncturists and acupuncture believers think that acupuncture can be useful in emergency situations, be they in the field ("battlefield acupuncture," anyone?) or in the ER. They even do studies purporting to show that. This is yet another of such a clinical trial, albeit larger than usual. Guess what? It doesn't really show what it's advertised to show. I explain...
Can mind-body practices “reprogram” our DNA?
A recent systematic review has been touted as demonstrating that "mind-body" practices like yoga can reprogram our DNA. There are several reasons to doubt these claims, not the least of which is the history of bias in past studies on this topic.